DNA methylation profiling in MEN1-related pancreatic neuroendocrine tumors reveals a potential epigenetic target for treatment

Fri, 08/10/2018 - 15:55 -- hwadmin
Highwire: apath: 
/eje/179/3/153.atom
Highwire: atom_id: 
tag:eje@highwire.org,2018-06-14:EJE-18-0195
Highwire: cpath: 
/content/179/3/153
Highwire: cpathalias: 
/content/eje/179/3/153
Highwire: jcode: 
eje
Highwire: pisa_id: 
eje;179/3/153
Highwire: pisa_master: 
eje;EJE-18-0195
Highwire: State: 
Released
Highwire: Type: 
article
Electronic Publication Date: 
Fri, 08/10/2018 - 15:55
First Page: 
153
Issue Number: 
3
Last Page: 
160
Print Publication Date: 
Sat, 09/01/2018
Slug: 
153
Highwire: Variants: 
abstract
full-text
figures-only
Volume Number: 
179
Category / TOC Heading: 
Clinical Study
Category / TOC Heading - Plural: 
Clinical Study
DOI - DEPRICATED: 
10.1530/EJE-18-0195
Open Access: 
0
Copyright Permissions: 
<nlm:permissions xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:hwp="http://schema.highwire.org/Journal"><nlm:copyright-statement hwp:id="copyright-statement-1">© 2018 European Society of Endocrinology</nlm:copyright-statement><nlm:copyright-year>2018</nlm:copyright-year><nlm:copyright-holder>European Society of Endocrinology</nlm:copyright-holder></nlm:permissions>
PubMed ID: 
29 903 750
Short Title: 
DNA methylation in PanNETs in MEN1
Article Type: 
Research Article
Version Type: 
Current Version
Journal Era: 
Sort Order: 
2 018 081 000 000 200.00
Custom Metadata: 
content-era e2
has-earlier-version yes
PDF - Depricated: 
Contributors: 
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<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>G J A Offerhaus</atom:name><nlm:aff><nlm:label><nlm:sup>4</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-4">Department of Pathology</nlm:institution><nlm:addr-line>University Medical Center Utrecht, Utrecht, The Netherlands</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Offerhaus G J A"><nlm:surname>Offerhaus</nlm:surname><nlm:given-names>G J A</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>C R C Pieterman</atom:name><nlm:aff><nlm:label><nlm:sup>2</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-2">Departments of Internal Medicine</nlm:institution><nlm:addr-line>University Medical Center Utrecht, Utrecht, The Netherlands</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Pieterman C R C"><nlm:surname>Pieterman</nlm:surname><nlm:given-names>C R C</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>F H Morsink</atom:name><nlm:aff><nlm:label><nlm:sup>4</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-4">Department of Pathology</nlm:institution><nlm:addr-line>University Medical Center Utrecht, Utrecht, The Netherlands</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Morsink F H"><nlm:surname>Morsink</nlm:surname><nlm:given-names>F H</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>O M Dekkers</atom:name><nlm:aff><nlm:label><nlm:sup>5</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-5">Departments of Endocrinology and Metabolism and Clinical Epidemiology</nlm:institution><nlm:addr-line>Leiden University Medical Center, Leiden, The Netherlands</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Dekkers O M"><nlm:surname>Dekkers</nlm:surname><nlm:given-names>O M</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>W W de Herder</atom:name><nlm:aff><nlm:label><nlm:sup>6</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-6">Department of Internal Medicine</nlm:institution><nlm:addr-line>Erasmus Medical Center, Rotterdam, The Netherlands</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="de Herder W W"><nlm:surname>de Herder</nlm:surname><nlm:given-names>W W</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>A R Hermus</atom:name><nlm:aff><nlm:label><nlm:sup>7</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-7">Department of Endocrinology</nlm:institution><nlm:addr-line>Radboud University Medical Center, Nijmegen, The Netherlands</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Hermus A R"><nlm:surname>Hermus</nlm:surname><nlm:given-names>A R</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>A N van der Horst-Schrivers</atom:name><nlm:aff><nlm:label><nlm:sup>8</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-8">Department of Endocrinology</nlm:institution><nlm:addr-line>University Medical Center Groningen, Groningen, The Netherlands</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="van der Horst-Schrivers A N"><nlm:surname>van der Horst-Schrivers</nlm:surname><nlm:given-names>A N</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>M L Drent</atom:name><nlm:aff><nlm:label><nlm:sup>3</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-3">Departments of Section Endocrinology</nlm:institution><nlm:addr-line>Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Drent M L"><nlm:surname>Drent</nlm:surname><nlm:given-names>M L</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>P H Bisschop</atom:name><nlm:aff><nlm:label><nlm:sup>9</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-9">Department of Endocrinology and Metabolism</nlm:institution><nlm:addr-line>Academic Medical Center, Amsterdam, The Netherlands</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Bisschop P H"><nlm:surname>Bisschop</nlm:surname><nlm:given-names>P H</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>B Havekes</atom:name><nlm:aff><nlm:label><nlm:sup>10</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-10">Division of Endocrinology</nlm:institution><nlm:addr-line>Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Havekes B"><nlm:surname>Havekes</nlm:surname><nlm:given-names>B</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>L A A Brosens</atom:name><nlm:aff><nlm:label><nlm:sup>4</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-4">Department of Pathology</nlm:institution><nlm:addr-line>University Medical Center Utrecht, Utrecht, The Netherlands</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Brosens L A A"><nlm:surname>Brosens</nlm:surname><nlm:given-names>L A A</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>K M A Dreijerink</atom:name><nlm:aff><nlm:label><nlm:sup>2</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-2">Departments of Internal Medicine</nlm:institution><nlm:addr-line>University Medical Center Utrecht, Utrecht, The Netherlands</nlm:addr-line></nlm:aff><nlm:aff><nlm:label><nlm:sup>3</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-3">Departments of Section Endocrinology</nlm:institution><nlm:addr-line>Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Dreijerink K M A"><nlm:surname>Dreijerink</nlm:surname><nlm:given-names>K M A</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>I H M Borel Rinkes</atom:name><nlm:aff><nlm:label><nlm:sup>1</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-1">Departments of Surgery</nlm:institution><nlm:addr-line>University Medical Center Utrecht, Utrecht, The Netherlands</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Borel Rinkes I H M"><nlm:surname>Borel Rinkes</nlm:surname><nlm:given-names>I H M</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>H Th M Timmers</atom:name><nlm:aff><nlm:label><nlm:sup>11</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-11">Regenerative Medicine Center and Center for Molecular Medicine</nlm:institution><nlm:addr-line>University Medical Center Utrecht, Utrecht, The Netherlands</nlm:addr-line></nlm:aff><nlm:aff><nlm:label><nlm:sup>12</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-12">German Cancer Consortium (DKTK) Partner Site Freiburg</nlm:institution><nlm:addr-line>German Cancer Research Center (DKFZ) and Department of Urology, Medical Center-University of Freiburg, Freiburg, Germany</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Timmers H Th M"><nlm:surname>Timmers</nlm:surname><nlm:given-names>H Th M</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>G D Valk</atom:name><nlm:aff><nlm:label><nlm:sup>2</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-2">Departments of Internal Medicine</nlm:institution><nlm:addr-line>University Medical Center Utrecht, Utrecht, The Netherlands</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Valk G D"><nlm:surname>Valk</nlm:surname><nlm:given-names>G D</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author" nlm:corresp="yes"><atom:name>M R Vriens</atom:name><atom:email>mvriens@umcutrecht.nl</atom:email><nlm:aff><nlm:label><nlm:sup>1</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-1">Departments of Surgery</nlm:institution><nlm:addr-line>University Medical Center Utrecht, Utrecht, The Netherlands</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Vriens M R"><nlm:surname>Vriens</nlm:surname><nlm:given-names>M R</nlm:given-names></nlm:name></atom:contributor>
First Publication Date: 
Thursday, June 14, 2018
Full Title: 
DNA methylation profiling in MEN1-related pancreatic neuroendocrine tumors reveals a potential epigenetic target for treatment
Early Release: 
GeoRef ID: 
Sub Component: 
Normal
DOI: 
10.1530/EJE-18-0195
Subtitle: 
Highwire: cme: 
no
Print ISSN: 
0804-4643
Electronic ISSN: 
1479-683X
Highwire Alternate Title: 
DNA methylation profiling in MEN1-related pancreatic neuroendocrine tumors reveals a potential epigenetic target for treatment
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Sunday, December 16, 2018 - 11:41
TOC Heading Full Title: 

<span class="wrapper">Clinical Study</span>

TOC Heading Plural Full Title: 

<span class="wrapper">Clinical Study</span>