Long-acting Fc-fusion rhGH (GX-H9) shows potential for up to twice-monthly administration in GH-deficient adults

Fri, 08/10/2018 - 15:55 -- hwadmin
Highwire: apath: 
/eje/179/3/169.atom
Highwire: atom_id: 
tag:eje@highwire.org,2018-07-04:EJE-18-0185
Highwire: cpath: 
/content/179/3/169
Highwire: cpathalias: 
/content/eje/179/3/169
Highwire: jcode: 
eje
Highwire: pisa_id: 
eje;179/3/169
Highwire: pisa_master: 
eje;EJE-18-0185
Highwire: State: 
Released
Highwire: Type: 
article
Electronic Publication Date: 
Fri, 08/10/2018 - 15:55
First Page: 
169
Issue Number: 
3
Last Page: 
179
Print Publication Date: 
Sat, 09/01/2018
Slug: 
169
Highwire: Variants: 
abstract
full-text
figures-only
Volume Number: 
179
Category / TOC Heading: 
Clinical Study
Category / TOC Heading - Plural: 
Clinical Study
DOI - DEPRICATED: 
10.1530/EJE-18-0185
Open Access: 
0
Copyright Permissions: 
<nlm:permissions xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:hwp="http://schema.highwire.org/Journal"><nlm:copyright-statement hwp:id="copyright-statement-1">© 2018 European Society of Endocrinology</nlm:copyright-statement><nlm:copyright-year>2018</nlm:copyright-year><nlm:copyright-holder>European Society of Endocrinology</nlm:copyright-holder></nlm:permissions>
PubMed ID: 
29 973 375
Short Title: 
Phase 1b/2 study of GX-H9 in adult GHD
Article Type: 
Research Article
Version Type: 
Current Version
Journal Era: 
Sort Order: 
2 018 081 000 000 200.00
Custom Metadata: 
content-era e2
has-earlier-version yes
r_released 2018-08-10T03:25:58-07:00
a_published 2018-07-04T03:11:40-07:00
PDF - Depricated: 
Contributors: 
<atom:author xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Cheol Ryong Ku</atom:name><nlm:aff><nlm:label><nlm:sup>1</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-1">Endocrinology</nlm:institution><nlm:addr-line>Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Ku Cheol Ryong"><nlm:surname>Ku</nlm:surname><nlm:given-names>Cheol Ryong</nlm:given-names></nlm:name></atom:author>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Thierry Brue</atom:name><nlm:aff><nlm:label><nlm:sup>2</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-2">Aix-Marseille Université</nlm:institution><nlm:addr-line>INSERM U1251, Marseille Medical Genetics, and AP-HM, Hôpital Conception, Marseille, France</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Brue Thierry"><nlm:surname>Brue</nlm:surname><nlm:given-names>Thierry</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Katharina Schilbach</atom:name><nlm:aff><nlm:label><nlm:sup>3</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-3">Medizinische Klinik und Poliklinik IV</nlm:institution><nlm:addr-line>Klinikum der Universität München, Munich, Germany</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Schilbach Katharina"><nlm:surname>Schilbach</nlm:surname><nlm:given-names>Katharina</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Stanislav Ignatenko</atom:name><nlm:aff><nlm:label><nlm:sup>4</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-4">Charité Research Organisation</nlm:institution><nlm:addr-line>Berlin, Germany</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Ignatenko Stanislav"><nlm:surname>Ignatenko</nlm:surname><nlm:given-names>Stanislav</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Sandor Magony</atom:name><nlm:aff><nlm:label><nlm:sup>5</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-5">First Department of Medicine</nlm:institution><nlm:addr-line>University of Szeged, Szeged, Hungary</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Magony Sandor"><nlm:surname>Magony</nlm:surname><nlm:given-names>Sandor</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Yoon-Sok Chung</atom:name><nlm:aff><nlm:label><nlm:sup>6</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-6">Department of Endocrinology and Metabolism</nlm:institution><nlm:addr-line>Ajou University School of Medicine, Suwon, Republic of Korea</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Chung Yoon-Sok"><nlm:surname>Chung</nlm:surname><nlm:given-names>Yoon-Sok</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Byung-Joon Kim</atom:name><nlm:aff><nlm:label><nlm:sup>7</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-7">Gachon University Gil Medical Center</nlm:institution><nlm:addr-line>Incheon, Republic of Korea</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Kim Byung-Joon"><nlm:surname>Kim</nlm:surname><nlm:given-names>Byung-Joon</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Kyu Yeon Hur</atom:name><nlm:aff><nlm:label><nlm:sup>8</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-8">Samsung Medical Center</nlm:institution><nlm:addr-line>Seoul, Republic of Korea</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Hur Kyu Yeon"><nlm:surname>Hur</nlm:surname><nlm:given-names>Kyu Yeon</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Ho-Cheol Kang</atom:name><nlm:aff><nlm:label><nlm:sup>9</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-9">Chonnam National University Hwasun Hospital</nlm:institution><nlm:addr-line>Hwasun-gun, Republic of Korea</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Kang Ho-Cheol"><nlm:surname>Kang</nlm:surname><nlm:given-names>Ho-Cheol</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Jung Hee Kim</atom:name><nlm:aff><nlm:label><nlm:sup>10</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-10">Seoul National University Hospital</nlm:institution><nlm:addr-line>Seoul, Republic of Korea</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Kim Jung Hee"><nlm:surname>Kim</nlm:surname><nlm:given-names>Jung Hee</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Min Seon Kim</atom:name><nlm:aff><nlm:label><nlm:sup>11</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-11">Asan Medical Center</nlm:institution><nlm:addr-line>Seoul, Republic of Korea</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Kim Min Seon"><nlm:surname>Kim</nlm:surname><nlm:given-names>Min Seon</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Aldona Kowalska</atom:name><nlm:aff><nlm:label><nlm:sup>12</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-12">Endocrinology Clinic Holycross Cancer Centre</nlm:institution><nlm:addr-line>Swietokrzyskie, Poland</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Kowalska Aldona"><nlm:surname>Kowalska</nlm:surname><nlm:given-names>Aldona</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Marek Bolanowski</atom:name><nlm:aff><nlm:label><nlm:sup>13</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-13">Department of Endocrinology</nlm:institution><nlm:addr-line>Diabetes and Isotope Therapy, Wroclaw Medical University, Wroclaw, Poland</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Bolanowski Marek"><nlm:surname>Bolanowski</nlm:surname><nlm:given-names>Marek</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Marek Ruchala</atom:name><nlm:aff><nlm:label><nlm:sup>14</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-14">Poznan University of Medical Sciences Chair and Department of Endocrinology</nlm:institution><nlm:addr-line>Metabolism and Internal Medicine, Poznań, Poland</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Ruchala Marek"><nlm:surname>Ruchala</nlm:surname><nlm:given-names>Marek</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Svetozar Damjanovic</atom:name><nlm:aff><nlm:label><nlm:sup>15</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-15">Clinical Center of Serbia</nlm:institution><nlm:addr-line>Belgrade, Serbia</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Damjanovic Svetozar"><nlm:surname>Damjanovic</nlm:surname><nlm:given-names>Svetozar</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Juraj Payer</atom:name><nlm:aff><nlm:label><nlm:sup>16</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-16">5th Department of Internal Medicine</nlm:institution><nlm:addr-line>Comenius University Faculty of Medicine, University Hospital, Bratislava, Slovakia</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Payer Juraj"><nlm:surname>Payer</nlm:surname><nlm:given-names>Juraj</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Yun Jung Choi</atom:name><nlm:aff><nlm:label><nlm:sup>17</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-17">Handok Inc.</nlm:institution><nlm:addr-line>Seoul, Republic of Korea</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Choi Yun Jung"><nlm:surname>Choi</nlm:surname><nlm:given-names>Yun Jung</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Su Jin Heo</atom:name><nlm:aff><nlm:label><nlm:sup>17</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-17">Handok Inc.</nlm:institution><nlm:addr-line>Seoul, Republic of Korea</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Heo Su Jin"><nlm:surname>Heo</nlm:surname><nlm:given-names>Su Jin</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Tae Kyoung Kim</atom:name><nlm:aff><nlm:label><nlm:sup>18</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-18">Genexine Inc.</nlm:institution><nlm:addr-line>Seongnam, Republic of Korea</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Kim Tae Kyoung"><nlm:surname>Kim</nlm:surname><nlm:given-names>Tae Kyoung</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>MinKyu Heo</atom:name><nlm:aff><nlm:label><nlm:sup>18</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-18">Genexine Inc.</nlm:institution><nlm:addr-line>Seongnam, Republic of Korea</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Heo MinKyu"><nlm:surname>Heo</nlm:surname><nlm:given-names>MinKyu</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Joan Lee</atom:name><nlm:aff><nlm:label><nlm:sup>18</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-18">Genexine Inc.</nlm:institution><nlm:addr-line>Seongnam, Republic of Korea</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Lee Joan"><nlm:surname>Lee</nlm:surname><nlm:given-names>Joan</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author" nlm:corresp="yes"><atom:name>Eun Jig Lee</atom:name><atom:email>ejlee423@yuhs.ac</atom:email><nlm:aff><nlm:label><nlm:sup>1</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-1">Endocrinology</nlm:institution><nlm:addr-line>Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Lee Eun Jig"><nlm:surname>Lee</nlm:surname><nlm:given-names>Eun Jig</nlm:given-names></nlm:name></atom:contributor>
First Publication Date: 
Wednesday, July 4, 2018
Full Title: 
Long-acting Fc-fusion rhGH (GX-H9) shows potential for up to twice-monthly administration in GH-deficient adults
Early Release: 
GeoRef ID: 
Sub Component: 
Normal
DOI: 
10.1530/EJE-18-0185
Subtitle: 
Highwire: cme: 
no
Print ISSN: 
0804-4643
Electronic ISSN: 
1479-683X
Highwire Alternate Title: 
Long-acting Fc-fusion rhGH (GX-H9) shows potential for up to twice-monthly administration in GH-deficient adults
Last load event: 
Sunday, December 16, 2018 - 11:41
TOC Heading Full Title: 

<span class="wrapper">Clinical Study</span>

TOC Heading Plural Full Title: 

<span class="wrapper">Clinical Study</span>