Should 45,X/46,XY boys with no or mild anomaly of external genitalia be investigated and followed up?

Fri, 08/10/2018 - 15:55 -- hwadmin
Highwire: apath: 
/eje/179/3/181.atom
Highwire: atom_id: 
tag:eje@highwire.org,2018-07-04:EJE-18-0309
Highwire: cpath: 
/content/179/3/181
Highwire: cpathalias: 
/content/eje/179/3/181
Highwire: jcode: 
eje
Highwire: pisa_id: 
eje;179/3/181
Highwire: pisa_master: 
eje;EJE-18-0309
Highwire: State: 
Released
Highwire: Type: 
article
Electronic Publication Date: 
Fri, 08/10/2018 - 15:55
First Page: 
181
Issue Number: 
3
Last Page: 
190
Print Publication Date: 
Sat, 09/01/2018
Slug: 
181
Highwire: Variants: 
abstract
full-text
figures-only
Volume Number: 
179
Category / TOC Heading: 
Clinical Study
Category / TOC Heading - Plural: 
Clinical Study
DOI - DEPRICATED: 
10.1530/EJE-18-0309
Open Access: 
0
Copyright Permissions: 
<nlm:permissions xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:hwp="http://schema.highwire.org/Journal"><nlm:copyright-statement hwp:id="copyright-statement-1">© 2018 European Society of Endocrinology</nlm:copyright-statement><nlm:copyright-year>2018</nlm:copyright-year><nlm:copyright-holder>European Society of Endocrinology</nlm:copyright-holder></nlm:permissions>
PubMed ID: 
29 973 376
Short Title: 
45,X/46,XY phenotypic boys, not so benign?
Article Type: 
Research Article
Version Type: 
Current Version
Journal Era: 
Sort Order: 
2 018 081 000 000 200.00
Custom Metadata: 
content-era e2
has-earlier-version yes
PDF - Depricated: 
Contributors: 
<atom:author xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Laurence Dumeige</atom:name><nlm:aff><nlm:label><nlm:sup>1</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-1">Pediatric Endocrinology Department</nlm:institution><nlm:addr-line>CHU Robert Debré, Centre de Référence des Maladies Endocriniennes Rares de la Croissance, Assistance-Publique Hôpitaux de Paris and Université Paris Diderot, Sorbonne Paris Cité, Paris, France</nlm:addr-line></nlm:aff><nlm:aff><nlm:label><nlm:sup>2</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-2">INSERM UMR-S1185</nlm:institution><nlm:addr-line>Le Kremlin Bicêtre, France</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Dumeige Laurence"><nlm:surname>Dumeige</nlm:surname><nlm:given-names>Laurence</nlm:given-names></nlm:name></atom:author>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Livie Chatelais</atom:name><nlm:aff><nlm:label><nlm:sup>3</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-3">Pediatric Department</nlm:institution><nlm:addr-line>CHU Angers, Angers, France</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Chatelais Livie"><nlm:surname>Chatelais</nlm:surname><nlm:given-names>Livie</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Claire Bouvattier</atom:name><nlm:aff><nlm:label><nlm:sup>4</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-4">Pediatric Endocrinology Department</nlm:institution><nlm:addr-line>CHU Bicêtre, Centre de Référence des Anomalies du Développement Génital, Assistance-Publique Hôpitaux de Paris, Le Kremlin-Bicêtre, France</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Bouvattier Claire"><nlm:surname>Bouvattier</nlm:surname><nlm:given-names>Claire</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Marc De Kerdanet</atom:name><nlm:aff><nlm:label><nlm:sup>5</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-5">Pediatric Department</nlm:institution><nlm:addr-line>CHU Rennes, Rennes, France</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="De Kerdanet Marc"><nlm:surname>De Kerdanet</nlm:surname><nlm:given-names>Marc</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Capucine Hyon</atom:name><nlm:aff><nlm:label><nlm:sup>6</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-6">Genetic Department</nlm:institution><nlm:addr-line>CHU Armand Trousseau, Centre de Référence des Maladies Endocriniennes Rares de la Croissance, Assistance-Publique Hôpitaux de Paris, Paris, France</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Hyon Capucine"><nlm:surname>Hyon</nlm:surname><nlm:given-names>Capucine</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Blandine Esteva</atom:name><nlm:aff><nlm:label><nlm:sup>7</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-7">Pediatric Endocrinology Department</nlm:institution><nlm:addr-line>CHU Armand Trousseau, Centre de Référence des Maladies Endocriniennes Rares de la Croissance, Assistance-Publique Hôpitaux de Paris, Paris, France</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Esteva Blandine"><nlm:surname>Esteva</nlm:surname><nlm:given-names>Blandine</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Dinane Samara-Boustani</atom:name><nlm:aff><nlm:label><nlm:sup>8</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-8">Pediatric Endocrinology Department</nlm:institution><nlm:addr-line>CHU Necker-Enfants Malades, Centre de Référence des Maladies Endocriniennes Rares de la Croissance, Assistance-Publique Hôpitaux de Paris, Paris, France</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Samara-Boustani Dinane"><nlm:surname>Samara-Boustani</nlm:surname><nlm:given-names>Dinane</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Delphine Zenaty</atom:name><nlm:aff><nlm:label><nlm:sup>1</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-1">Pediatric Endocrinology Department</nlm:institution><nlm:addr-line>CHU Robert Debré, Centre de Référence des Maladies Endocriniennes Rares de la Croissance, Assistance-Publique Hôpitaux de Paris and Université Paris Diderot, Sorbonne Paris Cité, Paris, France</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Zenaty Delphine"><nlm:surname>Zenaty</nlm:surname><nlm:given-names>Delphine</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Marc Nicolino</atom:name><nlm:aff><nlm:label><nlm:sup>9</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-9">Pediatric Endocrinology Department</nlm:institution><nlm:addr-line>CHU Lyon, Centre de Référence des Anomalies du Développement Génital, Lyon, France</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Nicolino Marc"><nlm:surname>Nicolino</nlm:surname><nlm:given-names>Marc</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Sabine Baron</atom:name><nlm:aff><nlm:label><nlm:sup>10</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-10">Pediatric Department CHU Nantes</nlm:institution><nlm:addr-line>Nantes, France</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Baron Sabine"><nlm:surname>Baron</nlm:surname><nlm:given-names>Sabine</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Chantal Metz-Blond</atom:name><nlm:aff><nlm:label><nlm:sup>11</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-11">Pediatric Department CHRU Brest</nlm:institution><nlm:addr-line>Brest, France</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Metz-Blond Chantal"><nlm:surname>Metz-Blond</nlm:surname><nlm:given-names>Chantal</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Catherine Naud-Saudreau</atom:name><nlm:aff><nlm:label><nlm:sup>12</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-12">Centre Hospitalier de Bretagne Sud</nlm:institution><nlm:addr-line>Lorient, France</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Naud-Saudreau Catherine"><nlm:surname>Naud-Saudreau</nlm:surname><nlm:given-names>Catherine</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Clémentine Dupuis</atom:name><nlm:aff><nlm:label><nlm:sup>13</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-13">CHU Grenoble</nlm:institution><nlm:addr-line>La Tronche, France</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Dupuis Clémentine"><nlm:surname>Dupuis</nlm:surname><nlm:given-names>Clémentine</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Juliane Léger</atom:name><nlm:aff><nlm:label><nlm:sup>1</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-1">Pediatric Endocrinology Department</nlm:institution><nlm:addr-line>CHU Robert Debré, Centre de Référence des Maladies Endocriniennes Rares de la Croissance, Assistance-Publique Hôpitaux de Paris and Université Paris Diderot, Sorbonne Paris Cité, Paris, France</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Léger Juliane"><nlm:surname>Léger</nlm:surname><nlm:given-names>Juliane</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Jean-Pierre Siffroi</atom:name><nlm:aff><nlm:label><nlm:sup>6</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-6">Genetic Department</nlm:institution><nlm:addr-line>CHU Armand Trousseau, Centre de Référence des Maladies Endocriniennes Rares de la Croissance, Assistance-Publique Hôpitaux de Paris, Paris, France</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Siffroi Jean-Pierre"><nlm:surname>Siffroi</nlm:surname><nlm:given-names>Jean-Pierre</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Bruno Donadille</atom:name><nlm:aff><nlm:label><nlm:sup>14</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-14">Endocrinology Department</nlm:institution><nlm:addr-line>CHU St-Antoine, Centre de Référence des Maladies Endocriniennes Rares de la Croissance, Assistance-Publique Hôpitaux de Paris, Paris, France</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Donadille Bruno"><nlm:surname>Donadille</nlm:surname><nlm:given-names>Bruno</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Sophie Christin-Maitre</atom:name><nlm:aff><nlm:label><nlm:sup>14</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-14">Endocrinology Department</nlm:institution><nlm:addr-line>CHU St-Antoine, Centre de Référence des Maladies Endocriniennes Rares de la Croissance, Assistance-Publique Hôpitaux de Paris, Paris, France</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Christin-Maitre Sophie"><nlm:surname>Christin-Maitre</nlm:surname><nlm:given-names>Sophie</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Jean-Claude Carel</atom:name><nlm:aff><nlm:label><nlm:sup>1</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-1">Pediatric Endocrinology Department</nlm:institution><nlm:addr-line>CHU Robert Debré, Centre de Référence des Maladies Endocriniennes Rares de la Croissance, Assistance-Publique Hôpitaux de Paris and Université Paris Diderot, Sorbonne Paris Cité, Paris, France</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Carel Jean-Claude"><nlm:surname>Carel</nlm:surname><nlm:given-names>Jean-Claude</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author"><atom:name>Regis Coutant</atom:name><nlm:aff><nlm:label><nlm:sup>2</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-2">INSERM UMR-S1185</nlm:institution><nlm:addr-line>Le Kremlin Bicêtre, France</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Coutant Regis"><nlm:surname>Coutant</nlm:surname><nlm:given-names>Regis</nlm:given-names></nlm:name></atom:contributor>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:xlink="http://www.w3.org/1999/xlink" nlm:contrib-type="author" nlm:corresp="yes"><atom:name>Laetitia Martinerie</atom:name><atom:email>laetitia.martinerie@aphp.fr</atom:email><nlm:aff><nlm:label><nlm:sup>1</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-1">Pediatric Endocrinology Department</nlm:institution><nlm:addr-line>CHU Robert Debré, Centre de Référence des Maladies Endocriniennes Rares de la Croissance, Assistance-Publique Hôpitaux de Paris and Université Paris Diderot, Sorbonne Paris Cité, Paris, France</nlm:addr-line></nlm:aff><nlm:aff><nlm:label><nlm:sup>2</nlm:sup></nlm:label><nlm:institution xlink:type="simple" hwp:id="institution-2">INSERM UMR-S1185</nlm:institution><nlm:addr-line>Le Kremlin Bicêtre, France</nlm:addr-line></nlm:aff><nlm:name name-style="western" hwp:sortable="Martinerie Laetitia"><nlm:surname>Martinerie</nlm:surname><nlm:given-names>Laetitia</nlm:given-names></nlm:name></atom:contributor>
First Publication Date: 
Wednesday, July 4, 2018
Full Title: 
Should 45,X/46,XY boys with no or mild anomaly of external genitalia be investigated and followed up?
Early Release: 
GeoRef ID: 
Sub Component: 
Normal
DOI: 
10.1530/EJE-18-0309
Subtitle: 
Highwire: cme: 
no
Print ISSN: 
0804-4643
Electronic ISSN: 
1479-683X
Highwire Alternate Title: 
Should 45,X/46,XY boys with no or mild anomaly of external genitalia be investigated and followed up?
Last load event: 
Sunday, December 16, 2018 - 11:41
TOC Heading Full Title: 

<span class="wrapper">Clinical Study</span>

TOC Heading Plural Full Title: 

<span class="wrapper">Clinical Study</span>